Demons in Doom Eternal bring their A game, and so do you. Many of the toughest demons carry devastating weapons and frustrating attributes, like the Arachnotron's cannon, which can be destroyed in order to reduce its effectiveness. These are considered "weak spots" and you should make an effort to target these areas and cripple demons for better control on the ground. You can't tear it apart if you're dead.
Arachnotron
This spider-shaped demon has a cannon mounted on its back. Projectiles are fast, hit hard, and can hit you from a distance. If left unchecked, it can devastate whatever is left of Doom Slayer's health bar. Destroy it with a well-placed sticky bomb. Warning: the arachnotrons will continue to chase you with miniature cannons on the sides.
Cacodemon
These one-eyed flying abominations have a big mouth. It turns out that this is their weak point. Throw a cluster grenade, ice grenade or sticky bomb into its mouth and watch it develop like a cartoon. In doing so, you'll stagger the Cacodemon, leaving it wide open for an eye-catching glory kill.
Pinky
Aptly named for their pink coloring, Pinky Demons are like raging bulls, rushing at you with such force that they can knock the Doom Slayer back a bit. If you dodge enough time, they will stop dead and slowly turn around. The Pinkys are terrible to shoot. This will give you the perfect window to hit them in the back, its weak spot, with the combat rifle or, better yet, a sticky bomb.
Mancubus
Like the Arachnotrons, the Mancubus are equipped with cannons that launch flaming projectiles. However, rather than having one mounted on his fat back, they have one in each hand. Aside from their long-range attacks, getting close and personal isn't a good idea as their cannons are equipped with flamethrowers. Take them out as quickly as possible with the Stick Bombs or the Heavy Cannon Precision mod. It even reduces the size of projectiles. Unfortunately, this tactic does not work with Cyber Mancubus.
Revenant
The Revenant skeleton is equipped with two shoulder cannons on its jetpack. If you choose to ignore them, the Revenant can lock onto you and fire multiple rockets. Its weak points are the two shoulder guns. Take out the two to avoid being a Doom Slayer gumbo. Once the cannons are destroyed, the RevENTS have no choice but to confront you with melee attacks.
Doom hunter
The Doom Hunter is a tank and a demon, floating around the terrain with a shield. Reaching his weak point, his sled, is more than aiming at him. First you need to remove his shield. Once the shield is broken - use the plasma rifle - aim at the sled and destroy it. Without the sled, its missiles and shield are disabled.
Maykr drone
Maykr drones are small armored angels that look similar to Khan Maykr. Their whole body is armored, except for their head which fires a barrage of energy projectiles. This is their weak spot and targeting it with a clean headshot will not only kill them, but also provide an abundance of ammo. They aren't terribly threatening if you keep moving, and killing them is as rewarding as a chainsaw attack. Keep them in case you run out of ammo.
Effectively target weak points
In the blur of combat, weak spots can be painful to hit. If only the demons stood still for half a second, you could hit them! To destroy weak points effectively, the Battle Rifle Sticky Bomb mod will be your best friend, as the blast ray is likely to damage the weak point if it does not destroy it completely. The Heavy Barrel's Precision Bolt mod is also a great alternative if you can hit them fast enough. Also use ice grenades if you have any problems.
